HSDB 5819
2-Picoline
CAS: 109-06-8;1333-41-1
Molecular Formula: C6H7N
HSDB 5819 - Names and Identifiers
| Name | 2-Picoline |
| Synonyms | NSC-3409 Picoline HSDB 5819 2-Picoline Methylpyridine 2-Methylpyidine α-Methylpyridine 2-Methylpyridine Pyridine, methyl- Pyridine, Reagent 2-picoline (alpha) 2-methylpyridine(2-Picoline) 2-Picoline (2-Methylpyridine) 2-Methylpyridine-d7(2-Picoline) |
| CAS | 109-06-8 1333-41-1 |
| EINECS | 203-643-7 |
| InChI | InChI=1/C6H7N/c1-6-4-2-3-5-7-6/h2-5H,1H3 |
| InChIKey | BSKHPKMHTQYZBB-UHFFFAOYSA-N |
HSDB 5819 - Physico-chemical Properties
| Molecular Formula | C6H7N |
| Molar Mass | 93.13 |
| Density | 0.942-0.946 at 20 °C0.943 g/mL at 25 °C (lit.) |
| Melting Point | -70 °C (lit.) |
| Boling Point | 128-129 °C (lit.) |
| Flash Point | 79°F |
| Water Solubility | MISCIBLE |
| Solubility | H2O: freely soluble |
| Vapor Presure | 10 mm Hg ( 24.4 °C) |
| Vapor Density | 3.2 (vs air) |
| Appearance | Liquid |
| Color | Clear pale yellow |
| Odor | Unpleasant |
| Merck | 14,7400 |
| BRN | 104581 |
| pKa | 5.97(at 20℃) |
| PH | 8.5 (100g/l, H2O, 20℃) |
| Storage Condition | Store below +30°C. |
| Stability | Stable. Flammable. Incompatible with strong oxidizing agents, sulfuric acid, acids, metals, iron (II) sulfate, hydrogen peroxide. Hygroscopic. |
| Sensitive | Hygroscopic |
| Explosive Limit | 1.4-8.6%(V) |
| Refractive Index | n20/D 1.500(lit.) |
| Physical and Chemical Properties | Trait a colorless oily liquid with a strong unpleasant pyridine odor. melting point -64 ℃ boiling point 129.5 ℃ relative density 0.9462 refractive index 1.4957 flash point 38.9 ℃ soluble in acetone and ether. Miscible with water and ethanol. |
| Use | It is used as a raw material for the synthesis of medicines, dyes and resins, and can be used to prepare fertilizer synergists, herbicides, livestock repellents, rubber accelerators, dye intermediates, etc. |
HSDB 5819 - Risk and Safety
| Risk Codes | R10 - Flammable R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37 - Irritating to eyes and respiratory system. R24 - Toxic in contact with skin R20/22 - Harmful by inhalation and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | UN 2313 3/PG 3 |
| WGK Germany | 1 |
| RTECS | TJ4900000 |
| TSCA | Yes |
| HS Code | 29333999 |
| Hazard Class | 3 |
| Packing Group | III |
| Toxicity | LD50 orally in rats: 1.41 g/kg (Smyth) |
HSDB 5819 - Upstream Downstream Industry
| Raw Materials | Benzene Ammonia Sulfuric acid |
| Downstream Products | Bisacodyl chlorphenamine hydrogen maleate 2-Pyridinealdoxime methochloride |
HSDB 5819 - Nature
Open Data Verified Data
natural oily liquid with the odor of pyridine. Spontaneous ignition point 537.8. Soluble in water, can be miscible with alcohol, ether. In case of open flame, high heat or contact with oxidant, there is a risk of combustion explosion. Toxic nitrogen oxide smoke is released by thermal decomposition. In case of high fever, the internal pressure of the container increases, and there is a risk of cracking and explosion.
Last Update：2025-06-10 22:55:16
HSDB 5819 - Preparation Method
Open Data Verified Data
The crude pyridine separated from coal tar is subjected to atmospheric distillation in a packed column, and the water in the pyridine is removed by azeotropic distillation of pure benzene and water, that is, 2 A methyl pyridine product. Alternatively, it is obtained by the reaction of an aldehyde with ammonia gas or by the catalytic reaction of acetylene and ammonia.
Last Update：2025-06-10 22:55:16
HSDB 5819 - Application
Open Data Verified Data
corrosion inhibitors for hydrochloric acid and other industrial pickling in acidizing and fracturing processes of oil and gas wells.
Last Update：2025-08-19 16:24:40
HSDB 5819 - Safety
Open Data Verified Data
rat oral LD50:1.41g/kg. Store in a cool, ventilated warehouse. Keep away from fire and heat source. The bin temperature should not exceed 30 ℃. Protection from direct sunlight. Keep the container sealed. Should be stored separately from the oxidant.
Last Update：2022-01-01 09:28:12
HSDB 5819 - Preparation or source
can be separated by tar base. The acetaldehyde method (reaction of acetaldehyde, formaldehyde and ammonia), the acetylene method (reaction of acetylene and ammonia), the ethylene method (reaction of ethylene and ammonia) and the acrylonitrile method (reaction of acrylonitrile with excess acetone) can also be used.
Last Update：2024-04-10 22:29:15
HSDB 5819 - Reference Information
| LogP | 1.11 at 20℃ |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Use | Used as a solvent and chromatography reagent, and also used in the organic synthesis industry 2-methylpyridine is an intermediate of the plant growth regulator pyridinol. It is used to make 2-vinylpyridine, nitrogen fertilizer synergist (N-Serve), long-acting sulfonamide, anti-silicosis drugs, livestock insect repellent, poultry drugs, organophosphorus antidote, local anesthetics, laxatives, film sensitizer additives, dye intermediates and rubber accelerators. It is used as a raw material for the synthesis of medicines, dyes, and resins. It can be used to produce fertilizer synergists, herbicides, livestock insect repellents, rubber accelerators, dye intermediates, etc. It is used for the synthesis of chemicals such as medicines, dyes, and rubber. It is also used as a solvent and experimental reagent to verify cobalt, cyanate and iron. Organic synthesis. |
| Production method | Pyridine and methylpyridine were previously recovered from coal coking by-products, which are distributed in coke oven gas, crude benzene and tar. Generally, the boiling point of pyridine hydrate transferred from coal gas to ammonium sulfate mother liquor is very low. Between 95-97 ℃, the crude light pyridine salt group recovered contains about 15% of 2-methylpyridine. Further distillation can be obtained to 2-methylpyridine. With the expansion of the use of pyridine and methylpyridine, the production of pyridine and methylpyridine by synthesis has been continuously developed. At present, about 95% of pyridine and pyridine compounds abroad are produced by synthetic method. The main synthesis methods include acetaldehyde method, acetylene method, acrylonitrile method, etc. The reaction of acetaldehyde, formaldehyde and ammonia by acetaldehyde method, the main products are 2-methylpyridine, 3-methylpyridine and 4-methylpyridine. Acetylene reaction acetylene and ammonia, the main products are 2-methylpyridine and 4-methylpyridine. The ethylene process reacts with ammonia, and the main products are 2-methylpyridine and 2-methyl-5-ethylpyridine. Acrylonitrile method acrylonitrile reacts with excess acetone, and the main product is 2-methylpyridine. In addition, the reaction of acrolein and ammonia mainly produces 3-methylpyridine. the preparation method is to use acetaldehyde as raw material, react with ammonia gas in the presence of catalyst, and the reaction temperature is 350~500 ℃ to obtain the product, and there is a by-product 4-methylpyridine. |
| category | flammable liquid |
| toxicity classification | poisoning |
| acute toxicity | oral-rat LD50: 790 mg/kg; Oral-mouse LD50: 674 mg/kg |
| stimulation data | skin-rabbit 10 mg/24 hours mild; Eye-rabbit 0.75 mg severe |
| explosive hazard characteristics | blastable when mixed with air |
| flammability hazard characteristics | it is more flammable in case of open flame, high temperature and oxidant; toxic nitrogen oxide gas generated by heating |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; Store separately from oxidants and acids |
| fire extinguishing agent | dry powder, dry sand, carbon dioxide, foam, 1211 fire extinguishing agent |
| auto-ignition temperature | 995 °F |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 02:00:05
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View History
Raw Materials for HSDB 5819
Downstream Products for HSDB 5819